Duonase
Duonase is a nasal spray made by Cipla that contains Azelastine 140 mcg per spray + Fluticasone 50 mcg per spray. It combines Azelastine: antihistamine (nasal spray) and Fluticasone: steroid (inhaled or nasal).
| Ingredient (salt) | Amount |
|---|---|
| Azelastine | 140 mcg per spray |
| Fluticasone | 50 mcg per spray |
Azelastine
What it is used for
Relieves sneezing, runny and itchy nose from allergies.
How it works
An antihistamine nasal spray (often with fluticasone) and eye drop for allergic rhinitis and conjunctivitis; works within 15 minutes.
How to take it
Nasal spray: 1 to 2 sprays per nostril twice a day.
Common side effects
- Bitter taste
- Drowsiness
- Nosebleeds
Get medical help straight away if
Allergic reaction
Be careful
Can leave a bitter taste; can cause mild drowsiness.
Other medicines and interactions
Drowsiness may add to alcohol and sedatives.
Pregnancy and breastfeeding
Ask your doctor before use in pregnancy and breastfeeding.
Fluticasone
What it is used for
Reduces airway or nasal inflammation in asthma and allergies.
How it works
A potent steroid used as an inhaler to prevent asthma and COPD flares, or as a nasal spray for allergic rhinitis.
How to take it
Inhaler: every day as prescribed, rinse mouth after use. Nasal spray: 1 to 2 sprays per nostril once daily, aiming slightly outwards; it takes a few days for full effect.
Common side effects
- Hoarseness
- Oral thrush
- Sore throat
- Nosebleeds (nasal spray)
- Headache
Get medical help straight away if
- White patches in the mouth
- Frequent nosebleeds
- Blurred vision
Be careful
Rinse your mouth after inhaler use.
Other medicines and interactions
Ritonavir, cobicistat, itraconazole and ketoconazole can raise its level enough to cause steroid side effects.
Pregnancy and breastfeeding
Inhaled and nasal forms are generally considered acceptable in pregnancy and breastfeeding when needed.
Common questions
What is Duonase?
Duonase is a nasal spray by Cipla containing Azelastine 140 mcg per spray + Fluticasone 50 mcg per spray.
What is Duonase used for?
Relieves sneezing, runny and itchy nose from allergies. Reduces airway or nasal inflammation in asthma and allergies.
How should I take Duonase?
Nasal spray: 1 to 2 sprays per nostril twice a day. Inhaler: every day as prescribed, rinse mouth after use. Nasal spray: 1 to 2 sprays per nostril once daily, aiming slightly outwards; it takes a few days for full effect. Always follow the dose your doctor or the pack gives.
What are the side effects of Duonase?
Common side effects include: Bitter taste, drowsiness, nosebleeds, Hoarseness, oral thrush, sore throat, nosebleeds (nasal spray), headache. Get medical help straight away for: Allergic reaction, White patches in the mouth, frequent nosebleeds, blurred vision.
Does Duonase need a prescription?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Can I take Duonase in pregnancy or while breastfeeding?
Ask your doctor before use in pregnancy and breastfeeding. Inhaled and nasal forms are generally considered acceptable in pregnancy and breastfeeding when needed.
What are the substitutes for Duonase?
We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.
Sources and further reading
- Azelastine: NHS · MedlinePlus
- Fluticasone: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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