Prothiaden 25

Tablet · Abbott
PRESCRIPTION MEDICINE

Prothiaden 25 is a tablet made by Abbott that contains Dothiepin 25 mg. Dothiepin is a tricyclic antidepressant: treats depression; in low doses sometimes for pain or sleep.

Ingredient (salt)Amount
Dothiepin (dosulepin)25 mg

What it is used for

Treats depression; in low doses sometimes for pain or sleep.

How it works

A tricyclic antidepressant (dosulepin) used for depression and sometimes chronic pain; very dangerous in overdose.

How to take it

Usually at night, as prescribed.

Common side effects

  • Dry mouth
  • Drowsiness
  • Constipation
  • Weight gain
  • Dizziness on standing

Get medical help straight away if

  • Fast or irregular heartbeat
  • Difficulty passing urine
  • Confusion
  • Thoughts of self-harm

Be careful

Causes drowsiness and dry mouth; dangerous in overdose.

Other medicines and interactions

Dangerous in overdose; keep away from children. More drowsiness with alcohol and sedatives. Serotonin syndrome risk with tramadol, SSRIs and triptans; avoid with MAOIs.

Pregnancy and breastfeeding

Ask your doctor; some tricyclics are used in pregnancy and breastfeeding at low doses when needed.

Common questions

What is Prothiaden 25?

Prothiaden 25 is a tablet by Abbott containing Dothiepin 25 mg.

What is Prothiaden 25 used for?

Treats depression; in low doses sometimes for pain or sleep.

How should I take Prothiaden 25?

Usually at night, as prescribed. Always follow the dose your doctor or the pack gives.

What are the side effects of Prothiaden 25?

Common side effects include: Dry mouth, drowsiness, constipation, weight gain, dizziness on standing. Get medical help straight away for: Fast or irregular heartbeat, difficulty passing urine, confusion, thoughts of self-harm.

Does Prothiaden 25 need a prescription?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Can I take Prothiaden 25 in pregnancy or while breastfeeding?

Ask your doctor; some tricyclics are used in pregnancy and breastfeeding at low doses when needed.

What are the substitutes for Prothiaden 25?

We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.