R-Cinex 450
R-Cinex 450 is a capsule made by Lupin that contains Rifampicin 450 mg + Isoniazid 300 mg. It combines Rifampicin: anti-tb antibiotic and Isoniazid: anti-tb antibiotic.
| Ingredient (salt) | Amount |
|---|---|
| Rifampicin | 450 mg |
| Isoniazid | 300 mg |
Rifampicin
What it is used for
Treats tuberculosis (TB) as part of a combination course.
How it works
A key TB antibiotic, always combined with others; also for leprosy and some serious infections.
How to take it
Take on an empty stomach, 30 minutes before breakfast, every day for the full course (often 6 months). Urine, tears and sweat turn orange-red; soft contact lenses can stain.
Common side effects
- Orange urine and tears (harmless)
- Nausea
- Flu-like symptoms with irregular use
Get medical help straight away if
- Yellow skin or eyes, dark urine, vomiting (liver)
- Bruising
Be careful
Turns urine and tears orange-red; many drug interactions including birth-control pills. Never stop the course early.
Other medicines and interactions
Makes many medicines much weaker, including the contraceptive pill (use condoms), warfarin, some HIV medicines, steroids and diabetes medicines.
Pregnancy and breastfeeding
Standard TB treatment is used in pregnancy (untreated TB is more dangerous) and while breastfeeding.
Isoniazid
What it is used for
Treats and prevents tuberculosis (TB).
How it works
A key TB antibiotic, used in combination treatment and alone to prevent TB.
How to take it
Usually once a day on an empty stomach, with vitamin B6 (pyridoxine) to protect nerves.
Common side effects
- Nausea
- Tingling in hands and feet
Get medical help straight away if
- Yellow skin, dark urine, loss of appetite (liver)
- Numbness
Be careful
Can cause tingling of hands and feet (vitamin B6 is usually given) and affect the liver. Never stop the course early.
Other medicines and interactions
Raises phenytoin and carbamazepine levels. Avoid alcohol (liver risk). Antacids reduce absorption.
Pregnancy and breastfeeding
Standard TB treatment is used in pregnancy (untreated TB is more dangerous) and while breastfeeding.
Common questions
What is R-Cinex 450?
R-Cinex 450 is a capsule by Lupin containing Rifampicin 450 mg + Isoniazid 300 mg.
What is R-Cinex 450 used for?
Treats tuberculosis (TB) as part of a combination course. Treats and prevents tuberculosis (TB).
How should I take R-Cinex 450?
Take on an empty stomach, 30 minutes before breakfast, every day for the full course (often 6 months). Urine, tears and sweat turn orange-red; soft contact lenses can stain. Usually once a day on an empty stomach, with vitamin B6 (pyridoxine) to protect nerves. Always follow the dose your doctor or the pack gives.
What are the side effects of R-Cinex 450?
Common side effects include: Orange urine and tears (harmless), nausea, flu-like symptoms with irregular use, Nausea, tingling in hands and feet. Get medical help straight away for: Yellow skin or eyes, dark urine, vomiting (liver), bruising, Yellow skin, dark urine, loss of appetite (liver), numbness.
Does R-Cinex 450 need a prescription?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Can I take R-Cinex 450 in pregnancy or while breastfeeding?
Standard TB treatment is used in pregnancy (untreated TB is more dangerous) and while breastfeeding. Standard TB treatment is used in pregnancy (untreated TB is more dangerous) and while breastfeeding.
What are the substitutes for R-Cinex 450?
We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.
Sources and further reading
- Rifampicin: NHS · MedlinePlus
- Isoniazid: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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