Ryzodeg
Ryzodeg is a injection (pen) made by Novo Nordisk / Abbott that contains Insulin degludec 70% + Insulin aspart 30%. It combines Insulin degludec: ultra-long-acting insulin and Insulin aspart: rapid-acting insulin.
| Ingredient (salt) | Amount |
|---|---|
| Insulin degludec | 70% |
| Insulin aspart | 30% |
Insulin degludec
What it is used for
Provides steady background insulin for over 24 hours in diabetes.
How it works
An ultra-long-acting basal insulin lasting more than 42 hours, giving a flat background effect.
How to take it
Inject once a day; the timing can vary if needed (at least 8 hours between doses). Inject under the skin of the tummy, thigh or upper arm, rotating sites. Never share pens. Store spare pens in the fridge (not frozen); the pen in use keeps at room temperature for about 4 weeks.
Common side effects
- Low blood sugar
- Weight gain
- Lumps or dents at injection sites if the same spot is used
Get medical help straight away if
Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food)
Be careful
Can cause low sugar; check sugar levels as advised.
Other medicines and interactions
Alcohol, missed meals and exercise lower sugar further; beta blockers can hide warning signs. Steroids raise sugar. Pioglitazone with insulin can cause fluid build-up.
Pregnancy and breastfeeding
Insulin is the standard treatment for diabetes in pregnancy and is safe while breastfeeding; doses change and need close monitoring.
Insulin aspart
What it is used for
Controls the rise in blood sugar after meals.
How it works
A rapid-acting mealtime insulin that starts working in 10 to 20 minutes.
How to take it
Inject 0 to 10 minutes before a meal (or just after in some cases). Inject under the skin of the tummy, thigh or upper arm, rotating sites. Never share pens. Store spare pens in the fridge (not frozen); the pen in use keeps at room temperature for about 4 weeks.
Common side effects
- Low blood sugar
- Weight gain
- Lumps or dents at injection sites if the same spot is used
Get medical help straight away if
Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food)
Be careful
Can cause low sugar; take with meals as advised.
Other medicines and interactions
Alcohol, missed meals and exercise lower sugar further; beta blockers can hide warning signs. Steroids raise sugar. Pioglitazone with insulin can cause fluid build-up.
Pregnancy and breastfeeding
Insulin is the standard treatment for diabetes in pregnancy and is safe while breastfeeding; doses change and need close monitoring.
Common questions
What is Ryzodeg?
Ryzodeg is a injection (pen) by Novo Nordisk / Abbott containing Insulin degludec 70% + Insulin aspart 30%.
What is Ryzodeg used for?
Provides steady background insulin for over 24 hours in diabetes. Controls the rise in blood sugar after meals.
How should I take Ryzodeg?
Inject once a day; the timing can vary if needed (at least 8 hours between doses). Inject under the skin of the tummy, thigh or upper arm, rotating sites. Never share pens. Store spare pens in the fridge (not frozen); the pen in use keeps at room temperature for about 4 weeks. Inject 0 to 10 minutes before a meal (or just after in some cases). Inject under the skin of the tummy, thigh or upper arm, rotating sites. Never share pens. Store spare pens in the fridge (not frozen); the pen in use keeps at room temperature for about 4 weeks. Always follow the dose your doctor or the pack gives.
What are the side effects of Ryzodeg?
Common side effects include: Low blood sugar, weight gain, lumps or dents at injection sites if the same spot is used, Low blood sugar, weight gain, lumps or dents at injection sites if the same spot is used. Get medical help straight away for: Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food), Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food).
Does Ryzodeg need a prescription?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Can I take Ryzodeg in pregnancy or while breastfeeding?
Insulin is the standard treatment for diabetes in pregnancy and is safe while breastfeeding; doses change and need close monitoring. Insulin is the standard treatment for diabetes in pregnancy and is safe while breastfeeding; doses change and need close monitoring.
What are the substitutes for Ryzodeg?
We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.
Sources and further reading
- Insulin degludec: NHS · MedlinePlus
- Insulin aspart: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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