Zerodol-MR
Zerodol-MR is a tablet made by Ipca that contains Aceclofenac 100 mg + Tizanidine 2 mg. It combines Aceclofenac: anti-inflammatory painkiller (nsaid) and Tizanidine: muscle relaxant.
| Ingredient (salt) | Amount |
|---|---|
| Aceclofenac | 100 mg |
| Tizanidine | 2 mg |
Aceclofenac
What it is used for
Eases pain and swelling in joints and muscles, such as arthritis, back pain and after injuries.
How it works
An NSAID closely related to diclofenac. It reduces prostaglandins, easing pain, inflammation and stiffness, and is often combined with paracetamol or serratiopeptidase.
How to take it
The usual adult dose is 100 mg twice a day after food. Swallow whole with water. It is meant for short courses unless a doctor is managing a long-term condition such as arthritis.
Common side effects
- Indigestion
- Stomach pain
- Nausea
- Diarrhoea
- Dizziness
- Raised liver enzymes
Get medical help straight away if
- Black stools or vomiting blood
- Chest pain or sudden breathlessness
- Swelling of legs or face
- Yellow eyes or skin
- Severe rash
Be careful
Take after food. Can cause acidity or stomach ulcers; caution with kidney or heart disease.
Other medicines and interactions
Do not take with other NSAIDs. Raises bleeding risk with blood thinners and SSRIs; may weaken blood pressure medicines and strain the kidneys with diuretics, ACE inhibitors or ARBs; can raise lithium and methotrexate levels.
Pregnancy and breastfeeding
Not recommended in pregnancy, and must be avoided in the last three months. Ask a doctor before using while breastfeeding; paracetamol or ibuprofen are usually preferred.
Tizanidine
What it is used for
Relaxes tight, painful muscles, for example in back and neck pain.
How it works
A muscle relaxant for spasticity (MS, spinal injury) and painful muscle spasm.
How to take it
Usually 2 to 4 mg up to three times a day, increased slowly; take consistently with or without food.
Common side effects
- Drowsiness
- Dry mouth
- Dizziness
- Weakness
- Low blood pressure
Get medical help straight away if
- Fainting
- Yellow skin
- Hallucinations
Be careful
Causes drowsiness and low blood pressure; avoid alcohol.
Other medicines and interactions
Must not be taken with ciprofloxacin or fluvoxamine (dangerous rise in level). The combined pill raises its level. More drowsiness with alcohol.
Pregnancy and breastfeeding
Not recommended in pregnancy or while breastfeeding.
Common questions
What is Zerodol-MR?
Zerodol-MR is a tablet by Ipca containing Aceclofenac 100 mg + Tizanidine 2 mg.
What is Zerodol-MR used for?
Eases pain and swelling in joints and muscles, such as arthritis, back pain and after injuries. Relaxes tight, painful muscles, for example in back and neck pain.
How should I take Zerodol-MR?
The usual adult dose is 100 mg twice a day after food. Swallow whole with water. It is meant for short courses unless a doctor is managing a long-term condition such as arthritis. Usually 2 to 4 mg up to three times a day, increased slowly; take consistently with or without food. Always follow the dose your doctor or the pack gives.
What are the side effects of Zerodol-MR?
Common side effects include: Indigestion, stomach pain, nausea, diarrhoea, dizziness, raised liver enzymes, Drowsiness, dry mouth, dizziness, weakness, low blood pressure. Get medical help straight away for: Black stools or vomiting blood, chest pain or sudden breathlessness, swelling of legs or face, yellow eyes or skin, severe rash, Fainting, yellow skin, hallucinations.
Does Zerodol-MR need a prescription?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Can I take Zerodol-MR in pregnancy or while breastfeeding?
Not recommended in pregnancy, and must be avoided in the last three months. Ask a doctor before using while breastfeeding; paracetamol or ibuprofen are usually preferred. Not recommended in pregnancy or while breastfeeding.
What are the substitutes for Zerodol-MR?
We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.
Sources and further reading
- Aceclofenac: NHS · MedlinePlus
- Tizanidine: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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