Chlorpheniramine
Chlorpheniramine is a antihistamine (older type) found in 6 medicines sold in India, such as Ascoril LD, Corex DX, Sinarest. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.
Also called: chlorphenamine, cpm
What it is used for
Reduces sneezing, runny nose, watery eyes and itching from colds and allergies.
How it works
An older antihistamine that blocks histamine and reduces sneezing, runny nose and itching; it also causes drowsiness.
How to take it
Adults usually take 4 mg every 4 to 6 hours, no more than 24 mg a day. Avoid driving if it makes you drowsy.
Common side effects
- Drowsiness
- Dry mouth
- Blurred vision
- Constipation
- Difficulty passing urine
Get medical help straight away if
- Confusion, fast heartbeat or inability to pass urine
- Allergic reaction
Be careful
Causes drowsiness; avoid driving and alcohol.
Other medicines and interactions
Drowsiness is much stronger with alcohol, sleeping pills, opioids and other sedating medicines. Take care with other anticholinergic medicines.
Pregnancy and breastfeeding
Has been used in pregnancy when needed, but ask a doctor first. Can make breastfed babies drowsy and may reduce milk supply; non-drowsy options are usually preferred.
Combination medicines that contain Chlorpheniramine (6)
Common questions
What is Chlorpheniramine used for?
Reduces sneezing, runny nose, watery eyes and itching from colds and allergies.
How does Chlorpheniramine work?
An older antihistamine that blocks histamine and reduces sneezing, runny nose and itching; it also causes drowsiness.
How should I take Chlorpheniramine?
Adults usually take 4 mg every 4 to 6 hours, no more than 24 mg a day. Avoid driving if it makes you drowsy.
What are the side effects of Chlorpheniramine?
Common: Drowsiness, dry mouth, blurred vision, constipation, difficulty passing urine. Get help straight away for: Confusion, fast heartbeat or inability to pass urine, allergic reaction.
Does Chlorpheniramine interact with other medicines?
Drowsiness is much stronger with alcohol, sleeping pills, opioids and other sedating medicines. Take care with other anticholinergic medicines.
Is Chlorpheniramine safe in pregnancy and breastfeeding?
Has been used in pregnancy when needed, but ask a doctor first. Can make breastfed babies drowsy and may reduce milk supply; non-drowsy options are usually preferred.
Does Chlorpheniramine need a prescription in India?
It is usually sold without a prescription in India, but ask a pharmacist if you take other medicines or have a long-term illness.
Which brands contain Chlorpheniramine?
Alex Syrup, Ascoril LD, Corex DX, Febrex Plus, Sinarest, Wikoryl.
Sources and further reading
- Chlorpheniramine: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.
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