Nimesulide

Anti-inflammatory painkiller (NSAID)
PRESCRIPTION ONLY IN INDIA

Nimesulide is a anti-inflammatory painkiller (NSAID) found in 2 medicines sold in India, such as Nise, Sumo. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

What it is used for

Short-term relief of pain, swelling and fever in adults.

How it works

A COX-2 preferring NSAID that eases pain, inflammation and fever. It is banned or restricted in many countries because of liver injury.

How to take it

Adults: 100 mg twice a day after food, for the shortest possible time and never longer than 15 days. Never give to children under 12.

Common side effects

  • Heartburn
  • Nausea
  • Stomach pain
  • Diarrhoea

Get medical help straight away if

  • Yellow skin or eyes
  • Dark urine
  • Pale stools
  • Loss of appetite with tiredness (signs of liver injury)
  • Severe rash

Be careful

Banned for children under 12 in India. Can harm the liver; use only for a few days.

Other medicines and interactions

Avoid alcohol, paracetamol overdoses and other medicines that strain the liver. Do not combine with other NSAIDs or blood thinners.

Pregnancy and breastfeeding

Not to be used in pregnancy (especially late pregnancy) or while breastfeeding.

Brands of Nimesulide (1)

Nise

Combination medicines that contain Nimesulide (1)

Sumo

Common questions

What is Nimesulide used for?

Short-term relief of pain, swelling and fever in adults.

How does Nimesulide work?

A COX-2 preferring NSAID that eases pain, inflammation and fever. It is banned or restricted in many countries because of liver injury.

How should I take Nimesulide?

Adults: 100 mg twice a day after food, for the shortest possible time and never longer than 15 days. Never give to children under 12.

What are the side effects of Nimesulide?

Common: Heartburn, nausea, stomach pain, diarrhoea. Get help straight away for: Yellow skin or eyes, dark urine, pale stools, loss of appetite with tiredness (signs of liver injury), severe rash.

Does Nimesulide interact with other medicines?

Avoid alcohol, paracetamol overdoses and other medicines that strain the liver. Do not combine with other NSAIDs or blood thinners.

Is Nimesulide safe in pregnancy and breastfeeding?

Not to be used in pregnancy (especially late pregnancy) or while breastfeeding.

Does Nimesulide need a prescription in India?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Which brands contain Nimesulide?

Nise, Sumo.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

🔎 Search another medicine

For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.