Pancreatin (pancreatic enzymes)

Digestive enzymes
PRESCRIPTION ONLY IN INDIA

Pancreatin is a digestive enzymes found in 1 medicine sold in India, such as Creon 25000. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

Also called: pancrelipase, pancreatin

What it is used for

Replaces missing pancreatic enzymes so food can be digested, for example in pancreatitis.

How it works

Pancreatic enzymes (lipase, amylase, protease) replace missing digestive enzymes in pancreatitis, cystic fibrosis and after pancreas surgery.

How to take it

Take with every meal and snack, swallowed whole; the dose matches the fat content of food.

Common side effects

  • Stomach pain
  • Nausea
  • Constipation or diarrhoea

Get medical help straight away if

Severe tummy pain or bowel blockage signs

Be careful

Swallow whole with meals; do not chew.

Other medicines and interactions

Antacids and acid reducers can change how well it works.

Pregnancy and breastfeeding

Used in pregnancy and breastfeeding when needed.

Brands of Pancreatin (1)

Creon 25000

Common questions

What is Pancreatin used for?

Replaces missing pancreatic enzymes so food can be digested, for example in pancreatitis.

How does Pancreatin work?

Pancreatic enzymes (lipase, amylase, protease) replace missing digestive enzymes in pancreatitis, cystic fibrosis and after pancreas surgery.

How should I take Pancreatin?

Take with every meal and snack, swallowed whole; the dose matches the fat content of food.

What are the side effects of Pancreatin?

Common: Stomach pain, nausea, constipation or diarrhoea. Get help straight away for: Severe tummy pain or bowel blockage signs.

Does Pancreatin interact with other medicines?

Antacids and acid reducers can change how well it works.

Is Pancreatin safe in pregnancy and breastfeeding?

Used in pregnancy and breastfeeding when needed.

Does Pancreatin need a prescription in India?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Which brands contain Pancreatin?

Creon 25000.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.