Simethicone

Anti-gas
ALSO SOLD WITHOUT PRESCRIPTION

Simethicone is a anti-gas found in 2 medicines sold in India, such as Gelusil MPS, Digene. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

Also called: dimethicone, activated dimethicone

What it is used for

Breaks up gas bubbles to ease bloating and wind.

How it works

An anti-foaming agent that breaks up gas bubbles in the gut so they are passed more easily. It is not absorbed into the body.

How to take it

Take after meals and at bedtime as directed; drops are used for infant colic.

Common side effects

Side effects are very rare

Get medical help straight away if

Severe or lasting stomach pain, vomiting or bloody stools

Be careful

Generally very safe.

Other medicines and interactions

Can reduce absorption of levothyroxine; separate by a few hours.

Pregnancy and breastfeeding

Not absorbed, so considered safe in pregnancy and breastfeeding.

Combination medicines that contain Simethicone (2)

DigeneGelusil MPS

Common questions

What is Simethicone used for?

Breaks up gas bubbles to ease bloating and wind.

How does Simethicone work?

An anti-foaming agent that breaks up gas bubbles in the gut so they are passed more easily. It is not absorbed into the body.

How should I take Simethicone?

Take after meals and at bedtime as directed; drops are used for infant colic.

What are the side effects of Simethicone?

Common: Side effects are very rare. Get help straight away for: Severe or lasting stomach pain, vomiting or bloody stools.

Does Simethicone interact with other medicines?

Can reduce absorption of levothyroxine; separate by a few hours.

Is Simethicone safe in pregnancy and breastfeeding?

Not absorbed, so considered safe in pregnancy and breastfeeding.

Does Simethicone need a prescription in India?

It is usually sold without a prescription in India, but ask a pharmacist if you take other medicines or have a long-term illness.

Which brands contain Simethicone?

Digene, Gelusil MPS.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.