Xylometazoline

Nasal decongestant spray
ALSO SOLD WITHOUT PRESCRIPTION

Xylometazoline is a nasal decongestant spray found in 1 medicine sold in India, such as Otrivin. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

What it is used for

Quickly clears a blocked nose from cold or sinusitis.

How it works

A nasal spray or drop that narrows blood vessels in the nose lining, relieving a blocked nose within minutes for up to 10 hours.

How to take it

Adults: 1 spray or 2 to 3 drops in each nostril up to 3 times a day. Use for no more than 5 to 7 days, or the blockage comes back worse (rebound congestion).

Common side effects

  • Stinging or dryness in the nose
  • Sneezing
  • Headache

Get medical help straight away if

  • Blocked nose gets worse after stopping (rebound)
  • Fast or irregular heartbeat

Be careful

Do not use for more than 5 to 7 days or the blockage can get worse (rebound).

Other medicines and interactions

Avoid with MAOI antidepressants. Children's strength is different; do not use adult sprays on children under 12.

Pregnancy and breastfeeding

Avoid in pregnancy if possible and use saline instead; ask a pharmacist about breastfeeding.

Brands of Xylometazoline (1)

Otrivin

Common questions

What is Xylometazoline used for?

Quickly clears a blocked nose from cold or sinusitis.

How does Xylometazoline work?

A nasal spray or drop that narrows blood vessels in the nose lining, relieving a blocked nose within minutes for up to 10 hours.

How should I take Xylometazoline?

Adults: 1 spray or 2 to 3 drops in each nostril up to 3 times a day. Use for no more than 5 to 7 days, or the blockage comes back worse (rebound congestion).

What are the side effects of Xylometazoline?

Common: Stinging or dryness in the nose, sneezing, headache. Get help straight away for: Blocked nose gets worse after stopping (rebound), fast or irregular heartbeat.

Does Xylometazoline interact with other medicines?

Avoid with MAOI antidepressants. Children's strength is different; do not use adult sprays on children under 12.

Is Xylometazoline safe in pregnancy and breastfeeding?

Avoid in pregnancy if possible and use saline instead; ask a pharmacist about breastfeeding.

Does Xylometazoline need a prescription in India?

It is usually sold without a prescription in India, but ask a pharmacist if you take other medicines or have a long-term illness.

Which brands contain Xylometazoline?

Otrivin.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.