Cobadex CZS
Cobadex CZS is a tablet made by GSK that contains Vitamin B complex nicotinamide 100 mg, pyridoxine 3 mg + Vitamin B12 15 mcg + Folic acid 1.5 mg + Zinc + Selenium 100 mcg + Chromium 250 mcg. It combines Vitamin B complex: vitamins, Vitamin B12: vitamin, Folic acid: vitamin, Zinc: mineral, Selenium: trace mineral and Chromium: trace mineral.
| Ingredient (salt) | Amount |
|---|---|
| Vitamin B complex | nicotinamide 100 mg, pyridoxine 3 mg |
| Vitamin B12 (methylcobalamin or cyanocobalamin) | 15 mcg |
| Folic acid | 1.5 mg |
| Zinc | see pack |
| Selenium | 100 mcg |
| Chromium | 250 mcg |
Vitamin B complex
What it is used for
Supports energy, nerves, skin and blood; used for deficiency and mouth ulcers.
How it works
A mix of B vitamins (B1, B2, B3, B5, B6 and often B12 and folic acid) needed for energy, nerves and making blood.
How to take it
Usually one a day after food. Bright yellow urine is harmless (from vitamin B2).
Common side effects
- Yellow urine
- Mild nausea
Get medical help straight away if
Numbness or tingling with very high B6 over months
Be careful
Urine may turn bright yellow; this is harmless.
Other medicines and interactions
High folic acid can hide B12 deficiency. B6 in large doses reduces levodopa effect (without carbidopa).
Pregnancy and breastfeeding
Prenatal vitamins are preferred in pregnancy; ordinary doses are fine while breastfeeding.
Vitamin B12 (methylcobalamin or cyanocobalamin)
What it is used for
Treats B12 deficiency, which can cause tiredness, anaemia and tingling in hands and feet.
How it works
Needed for nerves and red blood cells. Deficiency is common in vegetarians, older people and those on metformin or long-term acid reducers. Methylcobalamin and cyanocobalamin both work.
How to take it
Tablets once a day, or injections for severe deficiency or poor absorption. Nerve symptoms can take months to improve.
Common side effects
- Usually none
- Acne or rash rarely with injections
Get medical help straight away if
Allergic reaction to an injection
Be careful
Generally safe.
Other medicines and interactions
Metformin, PPIs and H2 blockers lower B12 absorption over time.
Pregnancy and breastfeeding
Safe in pregnancy and breastfeeding; vegetarian mothers often need it.
Folic acid
What it is used for
Prevents and treats anaemia and protects the baby's spine in early pregnancy.
How it works
A B vitamin (B9) needed to make new cells and red blood cells. Taken before and in early pregnancy it prevents spinal birth defects.
How to take it
400 mcg a day from before conception until 12 weeks of pregnancy (5 mg if advised for higher risk). For anaemia, as prescribed.
Common side effects
Usually none
Get medical help straight away if
Allergic reaction (rare)
Be careful
Generally safe.
Other medicines and interactions
High doses can hide B12 deficiency. Methotrexate, phenytoin and some antibiotics interfere with folate.
Pregnancy and breastfeeding
Strongly recommended before and during early pregnancy; safe while breastfeeding.
Zinc
What it is used for
Supports immunity, wound healing and growth; given with ORS in children's diarrhoea.
How it works
A mineral needed for immunity, skin healing and growth; with ORS it shortens diarrhoea in children.
How to take it
Children with diarrhoea: 10 to 20 mg a day for 10 to 14 days. Adults usually 10 to 25 mg a day with food.
Common side effects
- Nausea
- Metallic taste
- Stomach upset
Get medical help straight away if
Numbness or anaemia from long high-dose use (copper deficiency)
Be careful
Can cause nausea on an empty stomach.
Other medicines and interactions
Reduces absorption of quinolone and tetracycline antibiotics; separate by 2 to 4 hours. Iron and zinc compete with each other.
Pregnancy and breastfeeding
Normal doses are fine in pregnancy and breastfeeding.
Selenium
What it is used for
Part of the body's antioxidant defences; included in many multivitamins.
How it works
A trace mineral used by antioxidant enzymes and the thyroid; India's diet usually provides enough.
How to take it
Usually 50 to 200 mcg a day; do not exceed 400 mcg.
Common side effects
- Garlic breath
- Metallic taste
Get medical help straight away if
Hair loss, brittle nails or skin rash (too much)
Be careful
Too much over time is harmful (hair and nail changes).
Other medicines and interactions
High doses may add to blood-thinner effects.
Pregnancy and breastfeeding
Usual doses only; ask your doctor before taking supplements in pregnancy or while breastfeeding.
Chromium
What it is used for
Included in some supplements for blood sugar control.
How it works
A trace mineral claimed to help blood sugar control; evidence is weak.
How to take it
Usually 200 to 1,000 mcg a day.
Common side effects
- Headache
- Stomach upset
Get medical help straight away if
Dark urine or tiredness (rare kidney or liver effects)
Be careful
Not a replacement for diabetes medicines.
Other medicines and interactions
May add to the effect of diabetes medicines; check sugars.
Pregnancy and breastfeeding
Ask your doctor before taking supplements in pregnancy or while breastfeeding.
Most vitamin and herbal supplements in India are regulated as foods (FSSAI) and are not tested the way medicines are. More is not always better: check the dose on the pack, and tell your doctor about supplements you take.
Common questions
What is Cobadex CZS?
Cobadex CZS is a tablet by GSK containing Vitamin B complex nicotinamide 100 mg, pyridoxine 3 mg + Vitamin B12 15 mcg + Folic acid 1.5 mg + Zinc + Selenium 100 mcg + Chromium 250 mcg.
What is Cobadex CZS used for?
Supports energy, nerves, skin and blood; used for deficiency and mouth ulcers. Treats B12 deficiency, which can cause tiredness, anaemia and tingling in hands and feet. Prevents and treats anaemia and protects the baby's spine in early pregnancy. Supports immunity, wound healing and growth; given with ORS in children's diarrhoea. Part of the body's antioxidant defences; included in many multivitamins. Included in some supplements for blood sugar control.
How should I take Cobadex CZS?
Usually one a day after food. Bright yellow urine is harmless (from vitamin B2). Tablets once a day, or injections for severe deficiency or poor absorption. Nerve symptoms can take months to improve. 400 mcg a day from before conception until 12 weeks of pregnancy (5 mg if advised for higher risk). For anaemia, as prescribed. Children with diarrhoea: 10 to 20 mg a day for 10 to 14 days. Adults usually 10 to 25 mg a day with food. Usually 50 to 200 mcg a day; do not exceed 400 mcg. Usually 200 to 1,000 mcg a day. Always follow the dose your doctor or the pack gives.
What are the side effects of Cobadex CZS?
Common side effects include: Yellow urine, mild nausea, Usually none, acne or rash rarely with injections, Usually none, Nausea, metallic taste, stomach upset, Garlic breath, metallic taste, Headache, stomach upset. Get medical help straight away for: Numbness or tingling with very high B6 over months, Allergic reaction to an injection, Allergic reaction (rare), Numbness or anaemia from long high-dose use (copper deficiency), Hair loss, brittle nails or skin rash (too much), Dark urine or tiredness (rare kidney or liver effects).
Does Cobadex CZS need a prescription?
It is sold as a supplement and does not need a prescription.
Can I take Cobadex CZS in pregnancy or while breastfeeding?
Prenatal vitamins are preferred in pregnancy; ordinary doses are fine while breastfeeding. Safe in pregnancy and breastfeeding; vegetarian mothers often need it. Strongly recommended before and during early pregnancy; safe while breastfeeding. Normal doses are fine in pregnancy and breastfeeding. Usual doses only; ask your doctor before taking supplements in pregnancy or while breastfeeding. Ask your doctor before taking supplements in pregnancy or while breastfeeding.
What are the substitutes for Cobadex CZS?
We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.
Sources and further reading
- Vitamin B complex: NHS · MedlinePlus
- Vitamin B12 (methylcobalamin or cyanocobalamin): NHS · MedlinePlus
- Folic acid: NHS · MedlinePlus
- Zinc: NIH Office of Dietary Supplements · NHS · MedlinePlus
- Selenium: NIH Office of Dietary Supplements · NHS · MedlinePlus
- Chromium: NIH Office of Dietary Supplements · NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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