Enzoflam
Enzoflam is a tablet made by Alkem that contains Diclofenac + Paracetamol + Serratiopeptidase. It combines Diclofenac: anti-inflammatory painkiller (nsaid), Paracetamol: pain reliever and fever reducer and Serratiopeptidase: enzyme.
| Ingredient (salt) | Amount |
|---|---|
| Diclofenac | see pack |
| Paracetamol | see pack |
| Serratiopeptidase | see pack |
Diclofenac
What it is used for
Relieves pain and swelling from arthritis, sprains, back pain and dental pain.
How it works
An NSAID that blocks prostaglandin production. It is a strong, fast painkiller for inflammation-driven pain.
How to take it
Typical adult doses are 50 mg two or three times a day, or one 75 to 100 mg slow-release tablet daily, after food. Swallow slow-release tablets whole. Injections are given by a health professional.
Common side effects
- Indigestion
- Stomach pain
- Nausea
- Diarrhoea
- Headache
- Dizziness
Get medical help straight away if
- Black or bloody stools
- Chest pain, breathlessness or weakness on one side (heart attack or stroke signs)
- Yellow skin
- Much less urine
- Severe skin reaction
Be careful
Take after food. Can cause stomach bleeding and raise heart and kidney risk with long use.
Other medicines and interactions
Avoid with other NSAIDs and with blood thinners unless a doctor agrees. Can reduce the effect of blood pressure medicines and raise potassium and kidney risk with ACE inhibitors, ARBs and spironolactone. Raises lithium and methotrexate levels.
Pregnancy and breastfeeding
Avoid in the last three months of pregnancy and use earlier only on medical advice. Only small amounts pass into breast milk; short courses may be acceptable if a doctor agrees.
Paracetamol
What it is used for
Brings down fever and eases mild to moderate pain such as headache, body ache and toothache.
How it works
It works in the brain to raise the pain threshold and acts on the body's temperature centre to bring a fever down. Unlike NSAIDs it has little effect on swelling and is gentle on the stomach.
How to take it
Usual adult dose is 500 mg to 1 g every 4 to 6 hours, no more than 4 g (for example eight 500 mg tablets) in 24 hours; lower if you weigh under 50 kg, drink alcohol regularly or have liver disease. Children's doses go by weight. It can be taken with or without food.
Common side effects
- Side effects are rare at normal doses
- Occasionally rash or nausea
Get medical help straight away if
- You took more than the maximum dose, even if you feel well (liver damage shows up only after 1 to 3 days)
- Yellow skin or eyes
- A rash with blistering
Be careful
Too much damages the liver. Many cold and pain medicines also contain it, so avoid taking two at once; avoid with heavy alcohol use.
Other medicines and interactions
Many cold, flu and combination painkillers already contain paracetamol, so check every label to avoid a double dose. Regular high use can strengthen the effect of warfarin. Heavy alcohol use raises the risk of liver damage.
Pregnancy and breastfeeding
Paracetamol is the usual first choice for pain and fever in pregnancy and while breastfeeding, at the lowest dose that works for the shortest time.
Serratiopeptidase
What it is used for
Added to some painkillers to help reduce swelling after injury or dental work.
How it works
An enzyme from a gut bacterium that breaks down proteins. It is claimed to reduce swelling and thin mucus, but good quality evidence is weak.
How to take it
Usually 10 mg two or three times a day on an empty stomach, as part of a combination tablet, for a few days after injury or dental work.
Common side effects
- Stomach upset
- Nausea
- Loss of appetite
Get medical help straight away if
- Unusual bleeding or bruising
- Skin rash
Be careful
Evidence for its benefit is limited; caution if on blood thinners.
Other medicines and interactions
May add to bleeding risk with warfarin, clopidogrel, aspirin and other blood thinners.
Pregnancy and breastfeeding
Safety in pregnancy and breastfeeding is not established; avoid unless a doctor advises it.
Common questions
What is Enzoflam?
Enzoflam is a tablet by Alkem containing Diclofenac + Paracetamol + Serratiopeptidase.
What is Enzoflam used for?
Relieves pain and swelling from arthritis, sprains, back pain and dental pain. Brings down fever and eases mild to moderate pain such as headache, body ache and toothache. Added to some painkillers to help reduce swelling after injury or dental work.
How should I take Enzoflam?
Typical adult doses are 50 mg two or three times a day, or one 75 to 100 mg slow-release tablet daily, after food. Swallow slow-release tablets whole. Injections are given by a health professional. Usual adult dose is 500 mg to 1 g every 4 to 6 hours, no more than 4 g (for example eight 500 mg tablets) in 24 hours; lower if you weigh under 50 kg, drink alcohol regularly or have liver disease. Children's doses go by weight. It can be taken with or without food. Usually 10 mg two or three times a day on an empty stomach, as part of a combination tablet, for a few days after injury or dental work. Always follow the dose your doctor or the pack gives.
What are the side effects of Enzoflam?
Common side effects include: Indigestion, stomach pain, nausea, diarrhoea, headache, dizziness, Side effects are rare at normal doses, occasionally rash or nausea, Stomach upset, nausea, loss of appetite. Get medical help straight away for: Black or bloody stools, chest pain, breathlessness or weakness on one side (heart attack or stroke signs), yellow skin, much less urine, severe skin reaction, You took more than the maximum dose, even if you feel well (liver damage shows up only after 1 to 3 days), yellow skin or eyes, a rash with blistering, Unusual bleeding or bruising, skin rash.
Does Enzoflam need a prescription?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Can I take Enzoflam in pregnancy or while breastfeeding?
Avoid in the last three months of pregnancy and use earlier only on medical advice. Only small amounts pass into breast milk; short courses may be acceptable if a doctor agrees. Paracetamol is the usual first choice for pain and fever in pregnancy and while breastfeeding, at the lowest dose that works for the shortest time. Safety in pregnancy and breastfeeding is not established; avoid unless a doctor advises it.
What are the substitutes for Enzoflam?
We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.
Sources and further reading
- Diclofenac: NHS · MedlinePlus
- Paracetamol: NHS · MedlinePlus
- Serratiopeptidase: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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