Serratiopeptidase

Enzyme
PRESCRIPTION ONLY IN INDIA

Serratiopeptidase is a enzyme found in 15 medicines sold in India, such as Zerodol-SP, Enzoflam, Signoflam. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

Also called: serratio peptidase

What it is used for

Added to some painkillers to help reduce swelling after injury or dental work.

How it works

An enzyme from a gut bacterium that breaks down proteins. It is claimed to reduce swelling and thin mucus, but good quality evidence is weak.

How to take it

Usually 10 mg two or three times a day on an empty stomach, as part of a combination tablet, for a few days after injury or dental work.

Common side effects

  • Stomach upset
  • Nausea
  • Loss of appetite

Get medical help straight away if

  • Unusual bleeding or bruising
  • Skin rash

Be careful

Evidence for its benefit is limited; caution if on blood thinners.

Other medicines and interactions

May add to bleeding risk with warfarin, clopidogrel, aspirin and other blood thinners.

Pregnancy and breastfeeding

Safety in pregnancy and breastfeeding is not established; avoid unless a doctor advises it.

Combination medicines that contain Serratiopeptidase (15)

Aceclo SeraAcemiz-SAcenac-SpDolokind-AADolostat-SPDolowin ForteEnzoflamEnzoflam-SPFlozen-AAHifenac-DHifenac-SPKetorol SPMovexx SPSignoflamZerodol-SP

Common questions

What is Serratiopeptidase used for?

Added to some painkillers to help reduce swelling after injury or dental work.

How does Serratiopeptidase work?

An enzyme from a gut bacterium that breaks down proteins. It is claimed to reduce swelling and thin mucus, but good quality evidence is weak.

How should I take Serratiopeptidase?

Usually 10 mg two or three times a day on an empty stomach, as part of a combination tablet, for a few days after injury or dental work.

What are the side effects of Serratiopeptidase?

Common: Stomach upset, nausea, loss of appetite. Get help straight away for: Unusual bleeding or bruising, skin rash.

Does Serratiopeptidase interact with other medicines?

May add to bleeding risk with warfarin, clopidogrel, aspirin and other blood thinners.

Is Serratiopeptidase safe in pregnancy and breastfeeding?

Safety in pregnancy and breastfeeding is not established; avoid unless a doctor advises it.

Does Serratiopeptidase need a prescription in India?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Which brands contain Serratiopeptidase?

Aceclo Sera, Acemiz-S, Acenac-Sp, Dolokind-AA, Dolostat-SP, Dolowin Forte, Enzoflam, Enzoflam-SP, Flozen-AA, Hifenac-D, Hifenac-SP, Ketorol SP, Movexx SP, Signoflam, Zerodol-SP.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

🔎 Search another medicine

For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.