Glycomet-GP 0.5

Tablet · USV
PRESCRIPTION MEDICINE

Glycomet-GP 0.5 is a tablet made by USV that contains Metformin 0.5 mg + Glimepiride 500 mg. It combines Metformin: diabetes medicine (biguanide) and Glimepiride: diabetes medicine (sulfonylurea).

Ingredient (salt)Amount
Metformin0.5 mg
Glimepiride500 mg

Metformin

Diabetes medicine (biguanide)

What it is used for

Lowers blood sugar in type 2 diabetes, mainly by reducing sugar made by the liver.

How it works

The usual first medicine for type 2 diabetes. It lowers the amount of sugar the liver releases and helps the body respond to insulin. On its own it rarely causes low blood sugar and does not cause weight gain.

How to take it

Take with or just after meals to reduce stomach upset; start low (500 mg) and increase slowly. Slow-release tablets are gentler. Keep taking it unless your doctor says to stop.

Common side effects

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Metallic taste
  • Reduced appetite

Get medical help straight away if

  • Severe vomiting, fast breathing, muscle pain and unusual drowsiness (rare lactic acidosis)
  • Tingling feet or tiredness after years of use (low vitamin B12)

Be careful

Take with food; can cause stomach upset. Stop before scans with contrast or surgery if told.

Other medicines and interactions

Doctors pause it before scans with iodine contrast and before major surgery, and during dehydrating illness (vomiting, diarrhoea). Heavy alcohol raises lactic acidosis risk.

Pregnancy and breastfeeding

Sometimes continued in pregnancy under specialist care; insulin is often used. Considered acceptable while breastfeeding.

Glimepiride

Diabetes medicine (sulfonylurea)

What it is used for

Lowers blood sugar by making the pancreas release more insulin.

How it works

A sulfonylurea that makes the pancreas release more insulin, lowering blood sugar.

How to take it

Usually 1 to 4 mg once a day with breakfast or the first main meal. Do not skip meals after taking it.

Common side effects

  • Low blood sugar
  • Weight gain
  • Nausea

Get medical help straight away if

  • Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food)
  • Yellow skin
  • Rash

Be careful

Can cause low sugar (shaking, sweating); do not skip meals.

Other medicines and interactions

Low sugar is more likely with alcohol, other diabetes medicines, fluconazole, some antibiotics (clarithromycin, quinolones) and beta blockers, which can also hide the warning signs.

Pregnancy and breastfeeding

Usually switched to insulin in pregnancy. Not recommended while breastfeeding.

Same ingredients, different strength or form

Glycomet-GP 1Gemer 1Gemer 2Gluconorm-G 1Glimestar-M 1Glimisave-M 1Amaryl M 1Zoryl-M 1Glycomet-GP 2Amaryl M 2Zoryl-M 2Glimestar-M 2Glimisave-M 2Gluconorm-G 2Glyciphage-G 1Diapride M 1Geminor M1Azulix 1 MFGlucoryl-M1Gluformin G 1Glimy MGlador M1

Common questions

What is Glycomet-GP 0.5?

Glycomet-GP 0.5 is a tablet by USV containing Metformin 0.5 mg + Glimepiride 500 mg.

What is Glycomet-GP 0.5 used for?

Lowers blood sugar in type 2 diabetes, mainly by reducing sugar made by the liver. Lowers blood sugar by making the pancreas release more insulin.

How should I take Glycomet-GP 0.5?

Take with or just after meals to reduce stomach upset; start low (500 mg) and increase slowly. Slow-release tablets are gentler. Keep taking it unless your doctor says to stop. Usually 1 to 4 mg once a day with breakfast or the first main meal. Do not skip meals after taking it. Always follow the dose your doctor or the pack gives.

What are the side effects of Glycomet-GP 0.5?

Common side effects include: Diarrhoea, nausea, stomach pain, metallic taste, reduced appetite, Low blood sugar, weight gain, nausea. Get medical help straight away for: Severe vomiting, fast breathing, muscle pain and unusual drowsiness (rare lactic acidosis), tingling feet or tiredness after years of use (low vitamin B12), Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food), yellow skin, rash.

Does Glycomet-GP 0.5 need a prescription?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Can I take Glycomet-GP 0.5 in pregnancy or while breastfeeding?

Sometimes continued in pregnancy under specialist care; insulin is often used. Considered acceptable while breastfeeding. Usually switched to insulin in pregnancy. Not recommended while breastfeeding.

What are the substitutes for Glycomet-GP 0.5?

We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.