Glycomet Trio 2/0.3
Glycomet Trio 2/0.3 is a tablet made by USV that contains Metformin 500 mg + Glimepiride 2 mg + Voglibose 0.3 mg. It combines Metformin: diabetes medicine (biguanide), Glimepiride: diabetes medicine (sulfonylurea) and Voglibose: diabetes medicine (alpha-glucosidase inhibitor).
| Ingredient (salt) | Amount |
|---|---|
| Metformin | 500 mg |
| Glimepiride | 2 mg |
| Voglibose | 0.3 mg |
Metformin
What it is used for
Lowers blood sugar in type 2 diabetes, mainly by reducing sugar made by the liver.
How it works
The usual first medicine for type 2 diabetes. It lowers the amount of sugar the liver releases and helps the body respond to insulin. On its own it rarely causes low blood sugar and does not cause weight gain.
How to take it
Take with or just after meals to reduce stomach upset; start low (500 mg) and increase slowly. Slow-release tablets are gentler. Keep taking it unless your doctor says to stop.
Common side effects
- Diarrhoea
- Nausea
- Stomach pain
- Metallic taste
- Reduced appetite
Get medical help straight away if
- Severe vomiting, fast breathing, muscle pain and unusual drowsiness (rare lactic acidosis)
- Tingling feet or tiredness after years of use (low vitamin B12)
Be careful
Take with food; can cause stomach upset. Stop before scans with contrast or surgery if told.
Other medicines and interactions
Doctors pause it before scans with iodine contrast and before major surgery, and during dehydrating illness (vomiting, diarrhoea). Heavy alcohol raises lactic acidosis risk.
Pregnancy and breastfeeding
Sometimes continued in pregnancy under specialist care; insulin is often used. Considered acceptable while breastfeeding.
Glimepiride
What it is used for
Lowers blood sugar by making the pancreas release more insulin.
How it works
A sulfonylurea that makes the pancreas release more insulin, lowering blood sugar.
How to take it
Usually 1 to 4 mg once a day with breakfast or the first main meal. Do not skip meals after taking it.
Common side effects
- Low blood sugar
- Weight gain
- Nausea
Get medical help straight away if
- Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food)
- Yellow skin
- Rash
Be careful
Can cause low sugar (shaking, sweating); do not skip meals.
Other medicines and interactions
Low sugar is more likely with alcohol, other diabetes medicines, fluconazole, some antibiotics (clarithromycin, quinolones) and beta blockers, which can also hide the warning signs.
Pregnancy and breastfeeding
Usually switched to insulin in pregnancy. Not recommended while breastfeeding.
Voglibose
What it is used for
Slows sugar absorption from meals to reduce sugar spikes.
How it works
An alpha-glucosidase inhibitor that slows the breakdown of starch in the gut, reducing the rise in sugar after meals.
How to take it
Usually 0.2 to 0.3 mg three times a day, just before each meal.
Common side effects
- Wind
- Bloating
- Loose stools
Get medical help straight away if
- Severe stomach pain or swelling
- If low sugar happens with other medicines, treat with glucose, not table sugar
Be careful
Can cause gas and bloating; take just before meals.
Other medicines and interactions
With sulfonylureas or insulin, treat lows with glucose (dextrose), because ordinary sugar is absorbed slowly.
Pregnancy and breastfeeding
Not recommended in pregnancy or while breastfeeding.
Common questions
What is Glycomet Trio 2/0.3?
Glycomet Trio 2/0.3 is a tablet by USV containing Metformin 500 mg + Glimepiride 2 mg + Voglibose 0.3 mg.
What is Glycomet Trio 2/0.3 used for?
Lowers blood sugar in type 2 diabetes, mainly by reducing sugar made by the liver. Lowers blood sugar by making the pancreas release more insulin. Slows sugar absorption from meals to reduce sugar spikes.
How should I take Glycomet Trio 2/0.3?
Take with or just after meals to reduce stomach upset; start low (500 mg) and increase slowly. Slow-release tablets are gentler. Keep taking it unless your doctor says to stop. Usually 1 to 4 mg once a day with breakfast or the first main meal. Do not skip meals after taking it. Usually 0.2 to 0.3 mg three times a day, just before each meal. Always follow the dose your doctor or the pack gives.
What are the side effects of Glycomet Trio 2/0.3?
Common side effects include: Diarrhoea, nausea, stomach pain, metallic taste, reduced appetite, Low blood sugar, weight gain, nausea, Wind, bloating, loose stools. Get medical help straight away for: Severe vomiting, fast breathing, muscle pain and unusual drowsiness (rare lactic acidosis), tingling feet or tiredness after years of use (low vitamin B12), Low blood sugar: shaking, sweating, hunger, confusion or fainting (take 15 g of sugar such as glucose or juice, then food), yellow skin, rash, Severe stomach pain or swelling, if low sugar happens with other medicines, treat with glucose, not table sugar.
Does Glycomet Trio 2/0.3 need a prescription?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Can I take Glycomet Trio 2/0.3 in pregnancy or while breastfeeding?
Sometimes continued in pregnancy under specialist care; insulin is often used. Considered acceptable while breastfeeding. Usually switched to insulin in pregnancy. Not recommended while breastfeeding. Not recommended in pregnancy or while breastfeeding.
What are the substitutes for Glycomet Trio 2/0.3?
We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.
Sources and further reading
- Metformin: NHS · MedlinePlus
- Glimepiride: NHS · MedlinePlus
- Voglibose: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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