Heptral 400

Tablet · Abbott
PRESCRIPTION MEDICINE

Heptral 400 is a tablet made by Abbott that contains Ademetionine 400 mg. Ademetionine is a liver support: used in some liver conditions, such as poor bile flow.

Ingredient (salt)Amount
Ademetionine (SAMe)400 mg

What it is used for

Used in some liver conditions, such as poor bile flow.

How it works

S-adenosyl methionine (SAMe), used in some countries for liver bile flow problems and depression; evidence is mixed.

How to take it

Usually 400 to 1,600 mg a day on an empty stomach as prescribed.

Common side effects

  • Stomach upset
  • Trouble sleeping
  • Anxiety

Get medical help straight away if

Agitation or high mood

Be careful

Can cause stomach upset or sleep problems.

Other medicines and interactions

Serotonin syndrome risk with antidepressants and tramadol.

Pregnancy and breastfeeding

Ask a doctor before use in pregnancy and breastfeeding.

Common questions

What is Heptral 400?

Heptral 400 is a tablet by Abbott containing Ademetionine 400 mg.

What is Heptral 400 used for?

Used in some liver conditions, such as poor bile flow.

How should I take Heptral 400?

Usually 400 to 1,600 mg a day on an empty stomach as prescribed. Always follow the dose your doctor or the pack gives.

What are the side effects of Heptral 400?

Common side effects include: Stomach upset, trouble sleeping, anxiety. Get medical help straight away for: Agitation or high mood.

Does Heptral 400 need a prescription?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Can I take Heptral 400 in pregnancy or while breastfeeding?

Ask a doctor before use in pregnancy and breastfeeding.

What are the substitutes for Heptral 400?

We have no other brand with exactly the same composition and strength in our list yet. Ask your pharmacist for an equivalent.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.