Ademetionine (SAMe)

Liver support
PRESCRIPTION ONLY IN INDIA

Ademetionine is a liver support found in 1 medicine sold in India, such as Heptral 400. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

Also called: same, s-adenosyl methionine

What it is used for

Used in some liver conditions, such as poor bile flow.

How it works

S-adenosyl methionine (SAMe), used in some countries for liver bile flow problems and depression; evidence is mixed.

How to take it

Usually 400 to 1,600 mg a day on an empty stomach as prescribed.

Common side effects

  • Stomach upset
  • Trouble sleeping
  • Anxiety

Get medical help straight away if

Agitation or high mood

Be careful

Can cause stomach upset or sleep problems.

Other medicines and interactions

Serotonin syndrome risk with antidepressants and tramadol.

Pregnancy and breastfeeding

Ask a doctor before use in pregnancy and breastfeeding.

Brands of Ademetionine (1)

Heptral 400

Common questions

What is Ademetionine used for?

Used in some liver conditions, such as poor bile flow.

How does Ademetionine work?

S-adenosyl methionine (SAMe), used in some countries for liver bile flow problems and depression; evidence is mixed.

How should I take Ademetionine?

Usually 400 to 1,600 mg a day on an empty stomach as prescribed.

What are the side effects of Ademetionine?

Common: Stomach upset, trouble sleeping, anxiety. Get help straight away for: Agitation or high mood.

Does Ademetionine interact with other medicines?

Serotonin syndrome risk with antidepressants and tramadol.

Is Ademetionine safe in pregnancy and breastfeeding?

Ask a doctor before use in pregnancy and breastfeeding.

Does Ademetionine need a prescription in India?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Which brands contain Ademetionine?

Heptral 400.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.