Hifenac-D
Hifenac-D is a tablet made by Intas Pharma that contains Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 15 mg. It combines Aceclofenac: anti-inflammatory painkiller (nsaid), Paracetamol: pain reliever and fever reducer and Serratiopeptidase: enzyme.
| Ingredient (salt) | Amount |
|---|---|
| Aceclofenac | 100 mg |
| Paracetamol | 325 mg |
| Serratiopeptidase | 15 mg |
Aceclofenac
What it is used for
Eases pain and swelling in joints and muscles, such as arthritis, back pain and after injuries.
How it works
An NSAID closely related to diclofenac. It reduces prostaglandins, easing pain, inflammation and stiffness, and is often combined with paracetamol or serratiopeptidase.
How to take it
The usual adult dose is 100 mg twice a day after food. Swallow whole with water. It is meant for short courses unless a doctor is managing a long-term condition such as arthritis.
Common side effects
- Indigestion
- Stomach pain
- Nausea
- Diarrhoea
- Dizziness
- Raised liver enzymes
Get medical help straight away if
- Black stools or vomiting blood
- Chest pain or sudden breathlessness
- Swelling of legs or face
- Yellow eyes or skin
- Severe rash
Be careful
Take after food. Can cause acidity or stomach ulcers; caution with kidney or heart disease.
Other medicines and interactions
Do not take with other NSAIDs. Raises bleeding risk with blood thinners and SSRIs; may weaken blood pressure medicines and strain the kidneys with diuretics, ACE inhibitors or ARBs; can raise lithium and methotrexate levels.
Pregnancy and breastfeeding
Not recommended in pregnancy, and must be avoided in the last three months. Ask a doctor before using while breastfeeding; paracetamol or ibuprofen are usually preferred.
Paracetamol
What it is used for
Brings down fever and eases mild to moderate pain such as headache, body ache and toothache.
How it works
It works in the brain to raise the pain threshold and acts on the body's temperature centre to bring a fever down. Unlike NSAIDs it has little effect on swelling and is gentle on the stomach.
How to take it
Usual adult dose is 500 mg to 1 g every 4 to 6 hours, no more than 4 g (for example eight 500 mg tablets) in 24 hours; lower if you weigh under 50 kg, drink alcohol regularly or have liver disease. Children's doses go by weight. It can be taken with or without food.
Common side effects
- Side effects are rare at normal doses
- Occasionally rash or nausea
Get medical help straight away if
- You took more than the maximum dose, even if you feel well (liver damage shows up only after 1 to 3 days)
- Yellow skin or eyes
- A rash with blistering
Be careful
Too much damages the liver. Many cold and pain medicines also contain it, so avoid taking two at once; avoid with heavy alcohol use.
Other medicines and interactions
Many cold, flu and combination painkillers already contain paracetamol, so check every label to avoid a double dose. Regular high use can strengthen the effect of warfarin. Heavy alcohol use raises the risk of liver damage.
Pregnancy and breastfeeding
Paracetamol is the usual first choice for pain and fever in pregnancy and while breastfeeding, at the lowest dose that works for the shortest time.
Serratiopeptidase
What it is used for
Added to some painkillers to help reduce swelling after injury or dental work.
How it works
An enzyme from a gut bacterium that breaks down proteins. It is claimed to reduce swelling and thin mucus, but good quality evidence is weak.
How to take it
Usually 10 mg two or three times a day on an empty stomach, as part of a combination tablet, for a few days after injury or dental work.
Common side effects
- Stomach upset
- Nausea
- Loss of appetite
Get medical help straight away if
- Unusual bleeding or bruising
- Skin rash
Be careful
Evidence for its benefit is limited; caution if on blood thinners.
Other medicines and interactions
May add to bleeding risk with warfarin, clopidogrel, aspirin and other blood thinners.
Pregnancy and breastfeeding
Safety in pregnancy and breastfeeding is not established; avoid unless a doctor advises it.
Same composition, other brands (13)
Ask your doctor or pharmacist before switching brands.
Common questions
What is Hifenac-D?
Hifenac-D is a tablet by Intas Pharma containing Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 15 mg.
What is Hifenac-D used for?
Eases pain and swelling in joints and muscles, such as arthritis, back pain and after injuries. Brings down fever and eases mild to moderate pain such as headache, body ache and toothache. Added to some painkillers to help reduce swelling after injury or dental work.
How should I take Hifenac-D?
The usual adult dose is 100 mg twice a day after food. Swallow whole with water. It is meant for short courses unless a doctor is managing a long-term condition such as arthritis. Usual adult dose is 500 mg to 1 g every 4 to 6 hours, no more than 4 g (for example eight 500 mg tablets) in 24 hours; lower if you weigh under 50 kg, drink alcohol regularly or have liver disease. Children's doses go by weight. It can be taken with or without food. Usually 10 mg two or three times a day on an empty stomach, as part of a combination tablet, for a few days after injury or dental work. Always follow the dose your doctor or the pack gives.
What are the side effects of Hifenac-D?
Common side effects include: Indigestion, stomach pain, nausea, diarrhoea, dizziness, raised liver enzymes, Side effects are rare at normal doses, occasionally rash or nausea, Stomach upset, nausea, loss of appetite. Get medical help straight away for: Black stools or vomiting blood, chest pain or sudden breathlessness, swelling of legs or face, yellow eyes or skin, severe rash, You took more than the maximum dose, even if you feel well (liver damage shows up only after 1 to 3 days), yellow skin or eyes, a rash with blistering, Unusual bleeding or bruising, skin rash.
Does Hifenac-D need a prescription?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Can I take Hifenac-D in pregnancy or while breastfeeding?
Not recommended in pregnancy, and must be avoided in the last three months. Ask a doctor before using while breastfeeding; paracetamol or ibuprofen are usually preferred. Paracetamol is the usual first choice for pain and fever in pregnancy and while breastfeeding, at the lowest dose that works for the shortest time. Safety in pregnancy and breastfeeding is not established; avoid unless a doctor advises it.
What are the substitutes for Hifenac-D?
Brands with the same composition: Zerodol-SP, Signoflam, Dolostat-SP, Movexx SP, Dolokind-AA, Acemiz-S, Ketorol SP, Aceclo Sera, Flozen-AA, Acenac-Sp, Hifenac-SP, Enzoflam-SP. Ask your doctor or pharmacist before switching.
Sources and further reading
- Aceclofenac: NHS · MedlinePlus
- Paracetamol: NHS · MedlinePlus
- Serratiopeptidase: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Composition checked against pack details from large Indian online pharmacies. Last reviewed 31 October 2026. Written by Satya Babu.
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