Doxofylline

Bronchodilator
PRESCRIPTION ONLY IN INDIA

Doxofylline is a bronchodilator found in 1 medicine sold in India, such as Synasma 400. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

What it is used for

Opens the airways in asthma and COPD.

How it works

A theophylline-like bronchodilator with fewer heart and stomach side effects, popular in India for asthma and COPD.

How to take it

Usually 400 mg once or twice a day after food.

Common side effects

  • Nausea
  • Headache
  • Trouble sleeping
  • Palpitations

Get medical help straight away if

Very fast heartbeat, vomiting or seizures

Be careful

Can cause nausea or a fast heartbeat.

Other medicines and interactions

Erythromycin, ciprofloxacin and similar medicines can raise its levels. Avoid much caffeine.

Pregnancy and breastfeeding

Not recommended in pregnancy or while breastfeeding unless a doctor advises it.

Brands of Doxofylline (1)

Synasma 400

Common questions

What is Doxofylline used for?

Opens the airways in asthma and COPD.

How does Doxofylline work?

A theophylline-like bronchodilator with fewer heart and stomach side effects, popular in India for asthma and COPD.

How should I take Doxofylline?

Usually 400 mg once or twice a day after food.

What are the side effects of Doxofylline?

Common: Nausea, headache, trouble sleeping, palpitations. Get help straight away for: Very fast heartbeat, vomiting or seizures.

Does Doxofylline interact with other medicines?

Erythromycin, ciprofloxacin and similar medicines can raise its levels. Avoid much caffeine.

Is Doxofylline safe in pregnancy and breastfeeding?

Not recommended in pregnancy or while breastfeeding unless a doctor advises it.

Does Doxofylline need a prescription in India?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Which brands contain Doxofylline?

Synasma 400.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.