Sacubitril

Heart failure medicine
PRESCRIPTION ONLY IN INDIA

Sacubitril is a heart failure medicine found in 1 medicine sold in India, such as Vymada 50. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

What it is used for

Combined with valsartan to help a weak heart pump better and reduce hospital stays.

How it works

Blocks neprilysin, boosting the body's own natural salt- and water-removing hormones; always combined with valsartan for heart failure.

How to take it

Usually twice a day, increased gradually. Stop any ACE inhibitor 36 hours before starting.

Common side effects

  • Low blood pressure
  • Dizziness
  • High potassium
  • Cough

Get medical help straight away if

  • Swelling of the face or throat
  • Fainting
  • Much less urine

Be careful

Can lower blood pressure; not with ACE inhibitors or in pregnancy.

Other medicines and interactions

Never take with an ACE inhibitor. Potassium supplements and NSAIDs raise risk.

Pregnancy and breastfeeding

Must not be used in pregnancy; not recommended while breastfeeding.

Combination medicines that contain Sacubitril (1)

Vymada 50

Common questions

What is Sacubitril used for?

Combined with valsartan to help a weak heart pump better and reduce hospital stays.

How does Sacubitril work?

Blocks neprilysin, boosting the body's own natural salt- and water-removing hormones; always combined with valsartan for heart failure.

How should I take Sacubitril?

Usually twice a day, increased gradually. Stop any ACE inhibitor 36 hours before starting.

What are the side effects of Sacubitril?

Common: Low blood pressure, dizziness, high potassium, cough. Get help straight away for: Swelling of the face or throat, fainting, much less urine.

Does Sacubitril interact with other medicines?

Never take with an ACE inhibitor. Potassium supplements and NSAIDs raise risk.

Is Sacubitril safe in pregnancy and breastfeeding?

Must not be used in pregnancy; not recommended while breastfeeding.

Does Sacubitril need a prescription in India?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Which brands contain Sacubitril?

Vymada 50.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.