Vitamins

Vitamin D2 (ergocalciferol)

Also called: ergocalciferol, vitamin D2, calciferol

A plant or fungal form of vitamin D, often in prescription doses.

Why people take it
Low vitamin D.
What the evidence says
Raises vitamin D levels, a little less effectively than D3.
How it is usually taken
Doses similar to D3 (for example 1,000 to 2,000 IU a day or 50,000 IU weekly for deficiency); it raises blood levels less than D3. Made by UV-exposed mushrooms.
Be careful
Too much causes high calcium (nausea, kidney stones). Do not take large weekly doses without a test and a doctor.
Medicines it can interact with
Thiazide diuretics with high doses raise calcium. Orlistat, some anti-epileptics and steroids lower vitamin D.

Other vitamins

Common questions

What is Vitamin D2?

A plant or fungal form of vitamin D, often in prescription doses.

Why do people take Vitamin D2?

Low vitamin D.

Does Vitamin D2 work?

Raises vitamin D levels, a little less effectively than D3.

How much Vitamin D2 do people take?

Doses similar to D3 (for example 1,000 to 2,000 IU a day or 50,000 IU weekly for deficiency); it raises blood levels less than D3. Made by UV-exposed mushrooms.

Is Vitamin D2 safe?

Too much causes high calcium (nausea, kidney stones). Do not take large weekly doses without a test and a doctor.

Does Vitamin D2 interact with medicines?

Thiazide diuretics with high doses raise calcium. Orlistat, some anti-epileptics and steroids lower vitamin D.

Sources and further reading

Last reviewed 31 October 2026. Written by Satya Babu.

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For information only, not medical advice. Supplements are not medicines: they are not tested and approved like drugs before they are sold, and they can interact with medicines. Talk to your doctor or pharmacist before you start one, especially if you are pregnant or breastfeeding, take regular medicines, or have kidney, liver or heart disease.