Esomeprazole

Acid reducer (proton pump inhibitor)
PRESCRIPTION ONLY IN INDIA

Esomeprazole is a acid reducer (proton pump inhibitor) found in 18 medicines sold in India, such as Nexpro 40, Sompraz 40, Esoz 40. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.

What it is used for

Reduces stomach acid to treat reflux and ulcers.

How it works

A proton pump inhibitor (PPI), the purified active form of omeprazole, used for reflux, ulcers and with antibiotics to clear H. pylori.

How to take it

Take once a day, 30 to 60 minutes before breakfast, swallowed whole (do not crush or chew). Short courses of 2 to 8 weeks are usual; long-term use should be reviewed by a doctor.

Common side effects

  • Headache
  • Diarrhoea
  • Stomach pain
  • Nausea
  • Wind
  • Constipation

Get medical help straight away if

  • Watery diarrhoea that does not stop (possible C. difficile infection)
  • Difficulty swallowing, weight loss or black stools
  • Muscle cramps or spasms (low magnesium with long use)

Be careful

Take before food. Long-term use should be reviewed by a doctor.

Other medicines and interactions

Like omeprazole, it can reduce the effect of clopidogrel and raise levels of diazepam, phenytoin and warfarin.

Pregnancy and breastfeeding

Generally considered acceptable in pregnancy and breastfeeding when needed; ask your doctor.

Brands of Esomeprazole (17)

Esofag 40Esofence 40Esofine 40Esogress 40Esomac 40Esoz 40LupisozNeksium 40Nexium 40Nexpro 20Nexpro 40Nexpro Fast 40Raciper 40Sompraz 20Sompraz 40Sppi 40Yees 40

Combination medicines that contain Esomeprazole (1)

Nexpro RD

Common questions

What is Esomeprazole used for?

Reduces stomach acid to treat reflux and ulcers.

How does Esomeprazole work?

A proton pump inhibitor (PPI), the purified active form of omeprazole, used for reflux, ulcers and with antibiotics to clear H. pylori.

How should I take Esomeprazole?

Take once a day, 30 to 60 minutes before breakfast, swallowed whole (do not crush or chew). Short courses of 2 to 8 weeks are usual; long-term use should be reviewed by a doctor.

What are the side effects of Esomeprazole?

Common: Headache, diarrhoea, stomach pain, nausea, wind, constipation. Get help straight away for: Watery diarrhoea that does not stop (possible C. difficile infection), difficulty swallowing, weight loss or black stools, muscle cramps or spasms (low magnesium with long use).

Does Esomeprazole interact with other medicines?

Like omeprazole, it can reduce the effect of clopidogrel and raise levels of diazepam, phenytoin and warfarin.

Is Esomeprazole safe in pregnancy and breastfeeding?

Generally considered acceptable in pregnancy and breastfeeding when needed; ask your doctor.

Does Esomeprazole need a prescription in India?

Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.

Which brands contain Esomeprazole?

Esofag 40, Esofence 40, Esofine 40, Esogress 40, Esomac 40, Esoz 40, Lupisoz, Neksium 40, Nexium 40, Nexpro 20, Nexpro 40, Nexpro Fast 40, Nexpro RD, Raciper 40, Sompraz 20, Sompraz 40, Sppi 40, Yees 40.

Sources and further reading

NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.

Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.

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For information only, not medical advice. This page is a plain-language summary written from standard prescribing information and the public guides linked below. Brands sometimes change their formula, so always check the composition printed on the pack. Doses here are typical adult doses; yours may differ. Do not start, stop or change a medicine without your doctor or pharmacist, and keep all medicines away from children. In an emergency, call 112 (India) or your local emergency number.