Gut health

Betaine HCl

Also called: betaine hydrochloride, stomach acid

A form of acid sold to boost stomach acid.

Why people take it
Indigestion.
What the evidence says
Little evidence.
How it is usually taken
Usually 500 to 750 mg with protein meals; not for people with ulcers.
Be careful
Can worsen ulcers and heartburn; avoid with acid-reducing medicines.
Medicines it can interact with
Do not combine with NSAIDs or steroids (ulcer risk); works against acid reducers.

Other gut health

Common questions

What is Betaine HCl?

A form of acid sold to boost stomach acid.

Why do people take Betaine HCl?

Indigestion.

Does Betaine HCl work?

Little evidence.

How much Betaine HCl do people take?

Usually 500 to 750 mg with protein meals; not for people with ulcers.

Is Betaine HCl safe?

Can worsen ulcers and heartburn; avoid with acid-reducing medicines.

Does Betaine HCl interact with medicines?

Do not combine with NSAIDs or steroids (ulcer risk); works against acid reducers.

Sources and further reading

Last reviewed 31 October 2026. Written by Satya Babu.

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For information only, not medical advice. Supplements are not medicines: they are not tested and approved like drugs before they are sold, and they can interact with medicines. Talk to your doctor or pharmacist before you start one, especially if you are pregnant or breastfeeding, take regular medicines, or have kidney, liver or heart disease.