Gut health
Nattokinase
Also called: natto
An enzyme from fermented soybeans (natto).
- Why people take it
- Blood clots, circulation.
- What the evidence says
- Little good human evidence.
- How it is usually taken
- Usually 100 to 200 mg (2,000 to 4,000 FU) a day.
- Be careful
- May raise bleeding risk; do not combine with blood thinners.
- Medicines it can interact with
- Adds to bleeding risk with warfarin, aspirin and clopidogrel; stop before surgery.
Other gut health
Common questions
What is Nattokinase?
An enzyme from fermented soybeans (natto).
Why do people take Nattokinase?
Blood clots, circulation.
Does Nattokinase work?
Little good human evidence.
How much Nattokinase do people take?
Usually 100 to 200 mg (2,000 to 4,000 FU) a day.
Is Nattokinase safe?
May raise bleeding risk; do not combine with blood thinners.
Does Nattokinase interact with medicines?
Adds to bleeding risk with warfarin, aspirin and clopidogrel; stop before surgery.
Sources and further reading
Last reviewed 31 October 2026. Written by Satya Babu.
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