Amino acids

Glycine

Also called: glycine

A simple amino acid that is also a calming brain chemical.

Why people take it
Sleep, collagen production.
What the evidence says
Small studies suggest better sleep quality.
How it is usually taken
Usually 3 g at bedtime in sleep studies; 10 g or more with NAC in research on ageing.
Be careful
Generally safe. Avoid with clozapine.
Medicines it can interact with
May add to the effect of clozapine-type medicines; avoid with clozapine.

Other amino acids

Common questions

What is Glycine?

A simple amino acid that is also a calming brain chemical.

Why do people take Glycine?

Sleep, collagen production.

Does Glycine work?

Small studies suggest better sleep quality.

How much Glycine do people take?

Usually 3 g at bedtime in sleep studies; 10 g or more with NAC in research on ageing.

Is Glycine safe?

Generally safe. Avoid with clozapine.

Does Glycine interact with medicines?

May add to the effect of clozapine-type medicines; avoid with clozapine.

Sources and further reading

Last reviewed 31 October 2026. Written by Satya Babu.

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For information only, not medical advice. Supplements are not medicines: they are not tested and approved like drugs before they are sold, and they can interact with medicines. Talk to your doctor or pharmacist before you start one, especially if you are pregnant or breastfeeding, take regular medicines, or have kidney, liver or heart disease.