Proteins

HMB

Also called: beta-hydroxy beta-methylbutyrate, HMB

A compound the body makes from leucine.

Why people take it
Muscle preservation in older adults, recovery.
What the evidence says
May help muscle in older or inactive people; little benefit for trained athletes.
How it is usually taken
Usually 3 g a day in divided doses.
Be careful
Generally safe.
Medicines it can interact with
No important medicine interactions are known, but tell your doctor and pharmacist about every supplement you take.

Other proteins

Common questions

What is HMB?

A compound the body makes from leucine.

Why do people take HMB?

Muscle preservation in older adults, recovery.

Does HMB work?

May help muscle in older or inactive people; little benefit for trained athletes.

How much HMB do people take?

Usually 3 g a day in divided doses.

Is HMB safe?

Generally safe.

Does HMB interact with medicines?

No important medicine interactions are known, but tell your doctor and pharmacist about every supplement you take.

Sources and further reading

Last reviewed 31 October 2026. Written by Satya Babu.

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For information only, not medical advice. Supplements are not medicines: they are not tested and approved like drugs before they are sold, and they can interact with medicines. Talk to your doctor or pharmacist before you start one, especially if you are pregnant or breastfeeding, take regular medicines, or have kidney, liver or heart disease.