Domperidone
Domperidone is a anti-nausea, gut motility found in 38 medicines sold in India, such as Domstal, Vomistop, Domperon 10. Below: what it is for, how it works, how to take it, side effects, interactions and pregnancy advice.
What it is used for
Reduces nausea and vomiting and helps the stomach empty, easing bloating.
How it works
It blocks dopamine in the gut and in the vomiting centre, so food moves through the stomach faster and nausea eases. Often paired with a PPI.
How to take it
Adults usually take 10 mg up to three times a day, 15 to 30 minutes before meals, for no more than 7 days. Maximum 30 mg a day.
Common side effects
- Dry mouth
- Headache
- Stomach cramps
- Breast swelling or milk leakage
Get medical help straight away if
Fast or irregular heartbeat, fainting or palpitations (it can affect heart rhythm)
Be careful
Can affect heart rhythm at high doses; avoid with some heart conditions.
Other medicines and interactions
Do not combine with medicines that raise its level or affect heart rhythm: ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, amiodarone and some antipsychotics.
Pregnancy and breastfeeding
Avoid in pregnancy unless a doctor advises it. Passes into breast milk in small amounts; doctors sometimes prescribe it to boost milk, but only under supervision.
Brands of Domperidone (9)
Combination medicines that contain Domperidone (29)
Common questions
What is Domperidone used for?
Reduces nausea and vomiting and helps the stomach empty, easing bloating.
How does Domperidone work?
It blocks dopamine in the gut and in the vomiting centre, so food moves through the stomach faster and nausea eases. Often paired with a PPI.
How should I take Domperidone?
Adults usually take 10 mg up to three times a day, 15 to 30 minutes before meals, for no more than 7 days. Maximum 30 mg a day.
What are the side effects of Domperidone?
Common: Dry mouth, headache, stomach cramps, breast swelling or milk leakage. Get help straight away for: Fast or irregular heartbeat, fainting or palpitations (it can affect heart rhythm).
Does Domperidone interact with other medicines?
Do not combine with medicines that raise its level or affect heart rhythm: ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, amiodarone and some antipsychotics.
Is Domperidone safe in pregnancy and breastfeeding?
Avoid in pregnancy unless a doctor advises it. Passes into breast milk in small amounts; doctors sometimes prescribe it to boost milk, but only under supervision.
Does Domperidone need a prescription in India?
Yes. In India it is a prescription (Schedule H) medicine, so a pharmacist should sell it only with a doctor's prescription.
Which brands contain Domperidone?
Domel 10, Domipen 10, Domperon 10, Dompy 10, Domstal, Esoga-RD, Happi-D, Mahadom 10, Naxdom 500, Nexpro RD, Nupenta-DSR, Omez-D, Pan-D, Pansec DSR, Pantakind-DSR, Pantium DSR, Pantocid DSR, Pantodac DSR, Pantop-D, Pantosec DSR, Pentopan DSR, Protera D, Rabekind-DSR, Rabemac-DSR, Rabesec-D SR and 13 more.
Sources and further reading
- Domperidone: NHS · MedlinePlus
NHS (UK National Health Service) and MedlinePlus (US National Library of Medicine) are free, reviewed medicine guides. Brand names and doses there may differ from India.
Last reviewed 31 October 2026. Written by Satya Babu from standard prescribing information.
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